Asian Journal of Pharmaceutical Research and Health Care

R. Siva Kumar , P. Senthil Kumaran , P. Kumar Nallasivan , W. D. Sam Solomon , R. Venkatnarayanan

Abstract

A new simple, accurate, precise and reproducible Reverse Phase-High Performance Liquid Chromatographic method has been developed for the simultaneous estimation of Aceclofenac and Tizanidine in tablet dosage forms using C₁₈ column (Ineretsil, 250 x 4.6 mm, 5 μm) in isocratic mode. The mobile phase consisted of acetonitrile, methanol and 20 mM phosphate buffer adjusted to pH 3.5 in ratio of (40:30:30 v/v) with Ultraviolet-Visible detection at 230 nm. The method was linear over the concentration range for aceclofenac120-280 μg/ml and for tizanidine 2-40 μg/ml. The recoveries of Tizanidine and Aceclofenac were found to be in the range of 99.45-100.61% and 99.56-101.32% respectively. The validation of method was carried out using International Conference on Harmonization-guidelines. The described High Performance Liquid Chromatographic method was successfully employed for the analysis of pharmaceutical formulations containing combined dosage form.

Keywords

Simultaneous Estimation, RP - HPLC, Aceclofenac, Tizanidine, ICH Guidelines.

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T. Akelesh , R. Siva Kumar , R. Jothi , Vijairajan , P. Arulraj , R. Venkatnarayanan

Abstract

The aim of the present work is to analyze the standards of marketed cosmetic products which are largely consumed in day to day life of the people. The cosmeceutical should be tested for efficacy to ensure a proven skin benefit and also to substantiate marketing claims. The work was done by keeping the ideas of Bureau of Indian Standards to analyze the cosmetic products. The evaluation for the following cosmetics such as tooth pastes (Colgate, Closeup, Pepsodent, Vicco and Anchor) and face powders (Ponds, Eva, Fa, Cuticura and Spinz) are performed for their quality. All the marketed tooth pastes and face powders which had been evaluated complied with the standards specified by Bureau of Indian Standards. Hence all the selected marketed tooth pastes and selected face powders were found to be of good quality.

Keywords

Cosmetic Products, Bureau of Indian Standards, Tooth Paste, Face Powder.

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